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KMID : 0939920110430010067
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대한암학회지
2011 Volume.43 No. 1 p.67 ~ p.70
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Two Pediatric Osteosarcoma Cases with Delayed Methotrexate Excretion: Its Clinical Course and Management
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Lee Kang-Min
Lee Hee-Woo
Kim Seung-Yeon
Lee Hyeon-Jeong
Kim Dong-Hwan
Lim Jung-Sub
Lee Jin-Kyung
Lee Jun-Ah
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Abstract
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High-dose methotrexate (MTX) chemotherapy extends the duration of hospitalization and introduces the risks of serious complications related to delayed MTX excretion. The treatment of delayed MTX excretion is largely dependent on invasive measures such as hemodialysis because the clinical data regarding the efficacy or safety of carboxypetidase G2 is limited. We report here on the cases of two pediatric osteosarcoma patients with delayed MTX excretion and who were successfully managed using supportive measures. Potential life-threatening complications were prevented by administering high doses of leucovorin.
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KEYWORD
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Methotrexate, Osteosarcoma, Child, Complication, Management
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